2012 年 25 巻 4 号 p. 740-745
The process of bone regeneration on artificial mandible defects was evaluated after implanting titanium frame coated hydroxyapatite and fluoride-treated bioresorbable synthetic hydroxyapatite granules with a combination application of fluoride (4% NaF: 18,000 ppmF) and platelet-rich plasma (PRP) .
The titanium frame along with the surrounding bone was surgically removed four months after implantation and the crystal structure of the bone surface was measured by micro area X-ray diffraction (μ-XRD).
The two-dimensional μ-XRD pattern in the F-treated sample showed that the noise dispersion patterns of HA at 26.4 degrees, 28.6 degrees, 30.2 degrees, 36.1 degrees and 41.0 degrees had disappeared, which confirmed our in vitro data. Taken together with previous experiments, our study suggests that bioresorbable synthetic HA granules may improve the crystalline quality, although the unidentified pattern was considered to represent the existence of Monetite (CaPO3 (OH)) in the bioresorbable synthetic HA granules.
Therefore, the present results show that fluoride-released bioresorbable synthetic HA granules could be a promising method for clinical usage.
