インプラント植立時における上顎洞底挙上術骨造成部の病理組織学的検討

抄録

Purpose: The aim of this study was to establish bone components, starting time of new bone formation, quality, quantity and maturation of new bone at the regenerated site with reference to sinus lift surgery by histo-pathological analysis.
Materials and Method: The study group consisted of 81 core biopsy specimens of 2 mm in diameter and 8 mm in length taken by using a trephine bur, of 38 sinus lifts from 38 patients. These were divided into 10 groups: 61-90 days group, 91-120 days group, 121-150 days group, 151-180 days group, 181-210 days group, 211-240 days group, 241-270 days group, 271-300 days group, 301-330 days group and 331-365 days group after surgery. All core specimens were prepared for HE staining and antiPCNA antibody staining. New bone formation, new bone quality and quantity, mature bone and soft tissue were analyzed with the bone morphometrical method and the PCNA labeling index were calculated for all groups.
Results: 1.The formation of new bone was observed in the regenerated site of the sinus lift in the 61-90 days group. 2.The maturation of new bone in the regenerated site was observed in the 91-120 days group. 3.A large quantity of new bone in the regenerated site was observed in the 121-300 days group compared with the other groups, but only a small quantity of mature new bone was observed and the maturation of new bone was delayed in the regenerated site of the sinus lift. 4.A large volume of total bone area was observed compared with the other groups and was established in the 271-365 days group. 5.The PCNA labeling index was observed in the regenerated site of the sinus lift in all groups.
Conclusion: Active new bone formation was observed in the long term.