経口ビスフォスフォネート薬剤が下顎骨に与える影響について

抄録

Recovery of oral function with dental implants is clinically effective and highly predictable. The quantity and quality of bone at the implant installation site affect the prognosis, however, the effects of bisphosphonates (BP) on mandibular bone have not been well documented. The purpose of this study was to evaluate the effect of bisphosphonates on bone mineral density (BMD) and cortical width (CW) of the mandible.
The subjects were 41 female patients with a partially edentulous molar region of the mandible. Seventeen BP cases and 24 controls were evaluated. Cortical and trabecular BMD was measured with quantitative computed tomography (QCT). CW was measured with CT. The BMD and CW of the two groups were compared.
The results were as follows.
1. The use of oral bisphosphonates affected early implant failure rates.
2. Cortical BMD was significantly high in the BP group.
3. Trabecular BMD was not affected by BP.
4. CW was affected by the duration of taking BP.
These results indicate that BP affects the quality and quantity of cortical bone of the partially edentulous molar region of the mandible in patients with osteoporosis, which should be considered in dental implant treatment for patients taking BP.