The effects of repetitive administration of Cevimeline (SNI-2011), a novel muscarinic receptor agonist, (±) -cis-2-methylspilo [1, 3-oxathiolane-5, 3'-quinuclidine] hydrochlo-ride hemihydrate, on salivary secretion were studied in Balb/cA mice. Saliva flow, protein secretion and amylase activity were measured. Saliva was collected from the oral cavity at intervals of 5 min over 30 min after intraperitoneal injection of 10mg /kg of Cevimeline. The effects of 7 days of Cevimeline administration were compared with the effects of single injection.
Seven-day administration of Cevimeline tended to increase saliva flow over 30-min saliva collection compared with single injection. The rate of saliva release increased significantly in the first 10-min period. Protein concentration in the secreted saliva showed no significant change. The total amylase secretion over 30 min tended to increase.
The results of the present study showed the effects of chronic administration of Cevimeline in salivary function, and suggested that Cevimeline administration twice a day does not evoke tolerance in the salivary gland receptor.
