Abstract
Aims: To ascertain whether peripheral parenteral nutrition with a high-ratio lipid emulsion can be used safely.
Methods: The participants of this study were adult patients (n = 100) who required bowel rest. The nutrition dosage was determined based on the required energy level and amount of lipid emulsion per kg body mass, as calculated using the Harris-Benedict equation. Factors that were used to evaluate the usage safety included changes in parameters such as lipid levels, inflammatory reactions, liver function, and the presence or absence of adverse events. Hematological parameter was collected before commencing and after completion of peripheral parenteral nutrition.
Results: The average age of the patients was 71 years, average total energy dosage was 1,352 kcal/day, proportion of the total energy obtained from lipids was 60.9%, and average administration duration was 6.8 days. The levels of triglyceride and total cholesterol did not change significantly before and after nutrition dosage. Fasting blood glucose levels, prothrombin times, leukocyte and neutrophil counts, and bilirubin levels were decreased after dosage, compared with those before. No adverse events due to lipid emulsion were observed.
Conclusions: Lipid emulsions comprising 60% of the total energy dosage can be safely administered over a course of 1 week, causing no large changes in lipid metabolism.
