Drug Release Characteristic of Type 316L Stainless Steel with Self-Organized Nanopores

Abstract

Drug-releasing implants are attracting attention as a local drug delivery system（LDDS）with high drug efficiency and few side effects because they can administer drugs locally and continuously. Since the surface structure of implants is important for drug- releasing implants, many research reports have been made using metallic surfaces with nanostructures such as TiO 2 nanotubes as the platform for LDDS. In present study, we investigated drug release characteristic of collagen coated Type 316L stainless steel with self-organized nanopores formed by anodic polarization. Regardless of whether or not nanopore structure, the collagen coating treatment increased the amount of drug loaded on samples. The samples with nanopore structure suppressed burst release and increased the rate of slow release.