2008 Volume 28 Issue 1 Pages 49-54
A 22-year-old male was admitted to our hospital with high fever and arthralgia. He had a family history of sarcoidosis of the mother's sister and mother's cousin. He visited his family doctor complaining of continuing fever for one month and multiple arthralgia. His initial chest X-ray and CT showed bilateral hilar and mediastinal lymphadenopathy. Chest CT showed no pulmonary abnormality. Pathology of lung specimen obtained by trans-bronchial lung biopsy showed noncaseating epithelioid cell granuloma, suggesting sarcoidosis. No lymphocyte monoclonality was seen in this specimen. His symptom disappeared only with non-corticosteroid anti-inflammatory agents, and hilar and mediastinal lymphadenopathy on chest X-ray disappeared after one year follow up. Human leukocyte antigen (HLA) typing of this patient and his aunt showed A31 as the same locus.