規定された構造を有するクラスターによる脂質二重膜表面への欠陥導入

抄録

Nanomaterials has recently been expected as one of promising materials for functional anti-microbial agent, owing to their high activity high stability and low-cost fabrication process. Here, we have clarified the mechanism of destructive interaction of polyoxometalate (POM) clusters with the model cell membrane, by using both liposomes and solid-supported lipid bilayers. Leakage experiment clarified that liposomes are broken by POM cluster above a critical threshold concentration. At these concentrations, a formation of network-like defect in the solid-supported bilayer was found by fluorescence microscope observations. From correlations between results of liposome and supported bilayers, it was concluded that the formation of network-like defects formed above threshold concentration is the origin of destructive activity of POM for the cell membranes.