表面科学
Online ISSN : 1881-4743
Print ISSN : 0388-5321
ISSN-L : 0388-5321
特集:水の表面化学 —水を操る—
タンパク質吸着に及ぼす材料界面の水分子構造
—和周波発生分光法による解析から—
高井 まどか長澤 大樹東 倫之野口 秀典魚崎 浩平
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2014 年 35 巻 9 号 p. 492-497

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Adsorbed proteins initiate the undesirable phenomena like blood coagulation and immune response, and lead to the negative effects on human body and function of biodevices. Thus, the suppression of protein adsorption is essential property for biomaterials. Therefore, interfacial water molecules may play a key role on protein adsorption. In this study, various types of surface; hydrophobic, hydrophilic, anionic, cationic and zeitterionic were prepared by high-density polymer brush having different molecular structure. The amount of adsorbed negatively and positively charged protein was analyzed by quartz crystal microbalance (QCM) method to investigate the protein adsorption on polymer brush surfaces quantitatively. Structure of interfacial water at the interface between polymer brush and water media was investigated using sum-frequency generation (SFG) spectroscopy. From the quantitative comparison with protein adsorption and structure of interfacial water molecule of each polymer brush, it is concluded that the interfacial water molecules, which form strong hydrogen bonding is a strong relation to the suppression of protein adsorption.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc/4.0/deed.ja
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