表面科学
Online ISSN : 1881-4743
Print ISSN : 0388-5321
ISSN-L : 0388-5321
研究紹介
微細加工シリコンウェハ上での生細胞遊走観察
角南 寛清水 雄介横田 育子五十嵐 靖之岸本 英博松下 正之
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2017 年 38 巻 9 号 p. 473-478

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NIH-3T3 cells were adhered to three kinds of 3D micro-patterned scaffolds, placed face-down into culture medium in glass-bottomed dishes, and cell migration and the scaffolds were observed over 72 h. The three scaffolds differed only in terms of the unit shape of the repetitive pattern, namely a scale structure with equilateral triangular pores, a check structure with regular tetragonal pores, or a stripe structure with rectangular grooves. The angle that cells turn is influenced by the unit shape of the 3D patterned scaffold on which they are cultured. These differences in the angles that migrating cells turned correlated with differences in the angles they extended protrusions. In summary, the unit shape of the micro-patterned scaffold affects the angle at which cells extend, which in turn affects the angle at which migrating cells turn.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc/4.0/deed.ja
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