特異的細胞応答を目指した高分子表面デザイン

抄録

Detailed study on cell/materials interaction greatly contributes the molecular design of materials having a regulative effect on cellular functions. In this paper, special emphasis was placed on the molecular design of materials for cell separation. By controlling the distribution mode as well as the protonation degree of amino groups in polyamine graft copolymers, highly selective adsorption of a particular subpopulation of lymphocytes (B cells) on these copolymer surface was achieved, indicating a promising feature of these copolymers as adsorbent for lymphocyte separation. Further, a new cell separation method was established by hybridizing adhesion chromatography and fieldflow fractionation.