Recently, ion implantation has been applied to the surface modification of polymers, for example, ion implantation into proteins (extra-cellular matrix) to develop bio-compatible materials control of cell attachment and platelet in collagen, etc. In this report, ion implantation into the collagen coated inner surface of the polymer tube has been studied to develop hybrid type small diameter vascular grafts. Ion implantation was also applied to alter the surface properties of the catheter, which is used for the treatments of brain aneurysms, to improve their thrombogenicity and to promote wound healing of aneurysms.