チタンと生体組織の界面構造

抄録

The interface between metallic materials, especially titanium, and living cells (osteogenic cell) was investigated using a high-resolution transmission electron microscope, in order to establish the mechanism of the bio-compatibility for metals. At the titanium/cell interface there is an intermediate layer whose thickness is several ten nm involving not only metallic elements but also cell original elements. The intermediate layer does not have long/short range order or is rather complex structure. It is concluded that this intermediate layer is a mixture of titanium oxide and organic materials, which precipitates during cell culture. This precipitation of mixture is one of the advantages for titanium's biocompatibility. It is not cleared that calciumphosphate, one of the main composition of bone, precipitation on the surface on the material has any responsibility for bio-compatibility.