本邦における膵移植後患者における悪性腫瘍発生症例の検討

富丸 慶人; 伊藤 壽記; 丸橋 繁; 川本 弘一; 友國 晃; 浅岡 忠史; 濵 直樹; 和田 浩志; 小林 省吾; 江口 英利; 森 正樹; 土岐 祐一郎; 永野 浩昭

doi:10.11386/jst.49.348

De novo malignancies after pancreas transplantation in Japan

Yoshito Tomimaru, Toshinori Ito, Shigeru Marubashi, Koichi Kawamoto, Akira Tomokuni, Tadafumi Asaoka, Naoki Hama, Hiroshi Wada, Shogo Kobayashi, Hidetoshi Eguchi, Masaki Mori, Yuichiro Doki, Hiroaki Nagano

Author information

Yoshito Tomimaru
Department of Surgery, Graduate School of Medicine, Osaka University
Toshinori Ito
Department of Surgery, Graduate School of Medicine, Osaka University
Department of Complementary & Alternative Medicine, Graduate School of Medicine, Osaka University
Shigeru Marubashi
Department of Surgery, Graduate School of Medicine, Osaka University
Koichi Kawamoto
Department of Surgery, Graduate School of Medicine, Osaka University
Akira Tomokuni
Department of Surgery, Graduate School of Medicine, Osaka University
Tadafumi Asaoka
Department of Surgery, Graduate School of Medicine, Osaka University
Naoki Hama
Department of Surgery, Graduate School of Medicine, Osaka University
Hiroshi Wada
Department of Surgery, Graduate School of Medicine, Osaka University
Shogo Kobayashi
Department of Surgery, Graduate School of Medicine, Osaka University
Hidetoshi Eguchi
Department of Surgery, Graduate School of Medicine, Osaka University
Masaki Mori
Department of Surgery, Graduate School of Medicine, Osaka University
Yuichiro Doki
Department of Surgery, Graduate School of Medicine, Osaka University
Hiroaki Nagano
Department of Surgery, Graduate School of Medicine, Osaka University

Keywords: pancreas transplantation, de novo malignancy, neoplasm

JOURNAL FREE ACCESS

2014 Volume 49 Issue 4-5 Pages 348-352

DOI https://doi.org/10.11386/jst.49.348

Details

Abstract

【Background】Long-term immunosuppression is associated with an increased risk of cancer. Especially in pancreas transplantations, more intensive immunosuppression is used than in other organ transplantations because of strong immunogenicity. The aim of this studywas to analyze the incidence of de novo malignancies after pancreas transplantations in Japan.
【Methods】Posttransplant patients with de novo malignancies were surveyed and characterized.
【Results】Among 107 cases receiving a pancreas transplantation in Japan from 2001 to 2010, de novo malignancy developed in 9 cases; posttransplant lymphoproliferative disorder (PTLD) in 6, malignant brain tumor in 1, renal cell carcinoma in 1, and colon cancer in 1.
【Conclusions】We clarified the incidence of de novo malignancies after pancreas transplantation in Japan.

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