2016 年 51 巻 6 号 p. 423-428
The knowledge of antibody-mediated rejections in lung transplantations is quite limited compared with those in liver and kidney transplantations. In lung transplantation, an ABO-incompatible transplantation is basically contraindicated, and crossmatch-positive transplantations are also not widely performed. However, the importance of antibody-mediated rejections has been currently recognized by physicians and surgeons involved in lung transplantation. In the current international consensus statements, the monitoring of donor-specific antibodies and accumulation of diagnoses of antibody-mediated rejections have been recommended in lung transplant centers. These practices would soon clarify the true mechanism of antibody-mediated rejections including donor-specific antibodies, which will also pave the path to the establishment of their treatment.
