Thrombolysis with intravenous rt-PA for acute cerebral infarction was approved in Japan in 2005. The approval was so late among advanced countries in the world that we need to study hard to solve problems, not only of the therapy itself but also of those proper to our country.
To help this task, on-going clinical trials on this therapy in the world were surveyed via internet at http://clinicaltrails.gov/ and www.strokecenter.org/ and from the information at international congress of stroke in USA this year.
As the result, 29 on-going trials were found and divided in 8 groups, prolongation of time window, evaluation of tPA effect, combination with other drugs or therapy, intra-arterial therapy, drugs other than Alteplase, combination with ultrasound, application to the community and the data base. Essential information of each study was shown.