1984 年 6 巻 1 号 p. 38
From 1979 to 1982, 35 samples of cyclic AMP and cyclic GMP in plasma and 16 samples of those in CSF were determined in cases diagnosed as transient ischemic attacks. Among these patients 23 were males and 12 females. The age range was 43-81 years old (average 62.5). 23 cases occurred in the carotid system and 12 cases in the vertebro-basilar system. Method of study was modified Gilman's protein-bound method in group I (24 cases) and radioimmunoassay method in group II (11 cases).
The results of studies showed that plasma cAMP level was 40.58±28.86 pM/ml. (control 14.3±0.76) and CSF cAMP was 21.5±19.6 pM/ml. (control 13.0±0.71) in Goup I patients, and plasma cAMP level was 32.31±7.57 pM/ml. (control 23.22±0.51), cGMP level 17.23±4.31 pM/ml. (control 5.90±0.19); CSF level of cAMP was 16.04±2.75 pM/ml. (control 5.88±2.44), cGMP level 12.87±4.25 pM/ml. (control 2.33±1.88) in Group II patients. As compared to the normal control value, it seemed that cAMP and cGMP were significantly increased in plasma of TIA cases, but not so significant in CSF. Follow up studies showed that 4 cases who revealed higher cAMP levels in plasma, developed cerebral infarctions later, and the others usually showed better prognosis.