ウイルス
Online ISSN : 1884-3433
Print ISSN : 0042-6857
ISSN-L : 0042-6857
HVJとMumps Virusとの共通抗原性について 第3報
モルモット及鶏を用いての実験的証明
沼崎 義夫
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ジャーナル フリー

1960 年 10 巻 6 号 p. 366-374

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Common antigens shared by Sendai and mumps viruses was suggested in the former two experiments, where the first observation was made with clinical materials obtained from mumps patients and the second one was obtained in the field serological survey. Then the third experiment was conducted here in experimental animals, where antibody responses of both chicken and guinea pig against both Sendai and mumps viruses were examined every week for 5 weeks. In chicken, single intravenous administration was the choice of immunization procedure and obtained specimens were examined for their antibody titer on hemagglutination inhibition (HAI) and neutralization tests. In guinea pigs, the inoculum virus was given by instillation and the serum drawn every week was tested in HAI and complement fixation tests (CFT) with both viral and soluble antigens of each virus.
Obtained results will be summarized as follows:
1) In chicken, when mumps virus was used as an immunogen, antibody response against homologous virus was obtained in a uniform fashion with all tested chickens. Whereas one out of three, revealed parallel antibody shift against Sendai virus. In this case antibody titers were proved both in HAI and neutralization tests. When Sendai virus was used as an antigen, HAI titer against mumps virus was elicited with all three chickens examined so far.
2) In guinea pigs, when mumps virus was used for intranasal inoculation. HAI titer against Sendai virus as well as against homologous virus was proved with tested 4 guinea pigs. However, in CFT, no heterologous antibody was provable. On the other hand, when Sendai virus was used as an immunogen, any response against mumps virus was not provable.
In summary, shared antigenicity was provable between these two viruses not only with human specimens but also in animal experiments.

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