1,2-ジメチルヒドラジンの害作用に対するセレン強化カイワレダイコンスプラウトの影響

抄録

To evaluate health-promotional functions of selenium (Se)-enriched kaiware daikon sprouts (SeS), influence of SeS on adverse effects caused by 1,2-dimethylhydrazine (DMH) was compared with that of selenate or Se-unenriched sprouts (USeS). Male 3-week A/J mice were fed a diet containing a low level (0.15μg/g) or a high level (2.0μg/g) of Se as selenate or SeS or fed a diet containing the low or high level of selenate and USeS for 32 weeks. On the 1st to 5th week, all mice were administered with 20 mg/kg of DMH once a week. During the feeding, several mice were died. Supplementation with the both types of sprouts or the high level of selenate to the diets decreased the mortality. Low body weights were observed in mice fed the diets containing the high level of Se as selenate irrespective of supplementation with USeS. However, mice fed the diet containing the high level of Se as SeS did not show the low body weight. Lymphocyte permeation reaction (LPR) in large intestine was also examined in the all mice. Numbers of the LPR were decreased by supplementation with the high level of selenate or the both types of sprouts. In the present study, we could not confirm a difference between SeS and USeS in the influence on adverse effects by DMH. However, SeS can be used as a Se-enriched food without a high side effect since its toxicity is considered to be lower than selenate.