2011 Volume 28 Pages 40-44
Oyster is an old worldwide food containing abundant nutritional elements including many kinds of minerals such as zinc, nucleic acid, glycogen, and amino acids. It is reported that Oyster Extract Powder exhibits several physiological activities including anti-platelet aggregation effect in human and experimental animals. Recently, possible interaction between medical drugs and health foods has attracted the public attention, and in some health foods, occurrence of drug interaction is reported by concomitant ingestion with medical drugs. This time, we investigated the safety and possible drug interaction of Oyster Extract Powder in rabbits and rats.
Safety assessment by a 90 days repeated oral dose toxicity study in rats revealed no significant toxic effects of Oyster Extract Powder. Possible drug interaction was investigated with anti-platelet aggregation drugs including aspirin and ticlopidine, and anti-blood coagulation drug, warfarin, and no interaction was observed with any drugs. From these results, it was confirmed that Oyster Extract Powder is a safety health food showing no possible drug interaction with anti-platelet aggregation and anti-blood coagulation drugs.
In addition, glutathione level in hippocampus was analyzed since it was reported that Oyster Extract Powder increased glutathione levels. Then, significant increase in total glutathione level in hippocampus was noticed by administration of Oyster Extract Powder.
