Examination of the folic acid state during pregnancy

Abstract

A study reported that, during pregnancy, folic acid was involved in the continuation of pregnancy and fetal growth. However, there is no scientific evidence regarding optimal folic acid consumption in Japan. Folic acid deficiency results in the onset of neural tube defects such as spina bifida and anencephaly. We measured the blood level of folic acid in the first, second, and third trimesters of pregnancy in 28 pregnant women, and examined folic acid intake. The blood levels of folic acid in the first, second, and third trimesters of pregnancy were 0.27, 1.09, and 0.92 ng/mL, respectively. The mean folic acid intake was 235μg, being lower than that recommended in the Reference Intakes in Japanese [2010] (480μg). Trace nutrient consumption during pregnancy, including an additive volume, must be reviewed before pregnancy.