2013 Volume 30 Pages 48-51
Oyster is an old worldwide food containing abundant nutritional elements including many kinds of minerals such as zinc, nucleic acid, glycogen, and amino acids. It is reported that Oyster extract exhibits several physiological activities in experimental animals. Recently, we reported that Oyster extract enhanced hippocampus glutathione levels in rats. In general, glutathione is known as an antioxidant. On the other hand, Oxidative stress is a key factor of pathogenesis of dementia and Parkinson’s disease. This time, we investigated effect of Oyster extract by experimental Alzheimer-type dementia model of mouse and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced experimental parkinsonism model of mouse.
As a result, on experimental Alzheimer-type dementia model, Oyster extract tended to exert moderation effect on deficit memory in mice administered for 14 days or 28 days. Furthermore, on MPTP-induced experimental parkinsonism model, Oyster extract tended to exert moderation effect on parkinsonism in mice administered for 11 days.
