原著
A Standardized Extract of Glycine max co-cultured with Basidiomycota Improves Impaired Lipid Metabolism in High-Fat Diet- Fed Ovariectomized Mice
2023 年 40 巻 p. 40-45
詳細
2023 年 40 巻 p. 40-45
A standardized extract of Glycine max co-cultured with Basidiomycota (GCP®) is an isoflavone-rich soy extract. GCP® inhibits intracrine androgen synthesis in prostate cancer cells. Estrogen deficiency during menopause can alter lipid metabolism in the body, resulting in obesity and/or various disorders. In this study, the inhibitory effects of GCP® on altered lipid metabolism after menopause were investigated in ovariectomized C57BL/6JJmsSlc mice fed a high-fat diet (HFD). GCP® mice showed a significant decrease in total body weight concomitantly with weight loss of the perirenal adipose tissue as compared to that in control mice. Histological studies showed that GCP® inhibited HFD-induced fatty liver in these mice. mRNA expression levels of ATP-binding cassette protein G1 (ABCG1) and liver X receptor α (LXRα) were increased in liver of GCP® mice compared to that in control mice, whereas no changes were observed in the levels of ATPbinding cassette protein A1 (ABCA1), scavenger receptor class B type I (SR-BI), or low-density lipoprotein receptor (LDLR). Our preliminary results may suggest GCP® as a novel functional supplement candidate for inhibition of HFD-induced altered lipid metabolism after the menopause via the LXRα/ABCG1-dependent pathway.
