COVID-19 入院患者における血清亜鉛値と栄養指標との関連についての検討

抄録

We conducted a survey with the aim of identifying predictive factors for the risk of severe disease by determining the relationship between serum zinc levels and clinical indicators. The subjects were 124 patients who were diagnosed with SARS-CoV-2 nucleic acid or quantitative antigen levels and were hospitalized between April 1, 2021 and December 31, 2021. Average age was 52.1 ± 15.7 years, 77 men (62％)，47 women (38％)，Alb 3.9 ± 0.5 g/dL, CRP 5.9 ± 6.4 mg/dL, lymphocyte count 9.3 ± 4.3 million/ mm ³, serum zinc concentration was 57.6 ± 11.5 μg/dL, and PNI was 43.3 ± 5.4. A negative correlation was observed between serum zinc levels and CRP (r = -0.422; P< 0.001)，and a positive correlation was observed between serum zinc levels and PNI (r = 0.543; P< 0.001). As far as serum zinc concentrations were concerned, Alb and PNI were significantly lower in the zinc-deficient group than in other two groups, and CRP was higher in the zinc-deficient group than in other two groups. The results of this survey showed that abnormalities in CRP, lymphocyte count, serum zinc concentration, and PNI were observed as characteristics at the time of hospitalization COVID-19 infected patients. In conclusion, serum zinc levels may be closely related with inflammatory and nutritional biomarkers in patients with COVID-19.