1990 Volume 6 Pages 51-56
As previously reported, biodistribution studies with titanium-45 ascorbate (45Ti-AsA)has shown that the effects of AsA on biodistribution of Ti was remarkably characteristic in the kidney1). In this paper, using 45Ti-AsA, functional diagnosis of the kidney has been actively studied by animal models for renal disorder. As a technical requirements, autoradiography was selected. This work reveals the following results: 1) In Wistar rat which had made glomerulonephritis by injecting puromycin aminonucleoside2), the highest concentration of 45Ti was found in the cortex. 2) In stroke-prone spontaneously hypertensive rat ( SHRSP) fed a low protein and high sodium diet for four months which has the damage of renal tubule3) , the highest uptake of 45Ti was found in the medulla.
In conclusion, 45Ti was localized the damaged region of the kidney in each inflammation rat. 45Ti-AsA may be useful as a positron emmiting radiophrmaceutical or renal diagnosis.
