The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Letter
Evaluation of genotoxicity of amine-terminated water-dispersible FePt nanoparticles in the Ames test and in vitro chromosomal aberration test
Shinya MaenosonoRie YoshidaSoichiro Saita
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2009 Volume 34 Issue 3 Pages 349-354

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Abstract

Genotoxicity of superparamagnetic iron-platinum (FePt) nanoparticles (NPs) capped with 2-aminoethanethiol (AET) was evaluated using the bacterial reverse mutation assay (Ames test) and in vitro chromosomal aberration test. Mutagenicity of AET-capped FePt NPs was found to be negative in the Ames test, while clastogenicity of FePt NPs seemed to be false-positive in the in vitro chromosomal aberration test using Chinese hamster lung fibroblast cells. However, further detailed in vitro genotoxicity tests, such as DNA adduct studies, are necessary to conclude that a positive aberration result is irrelevant.

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© 2009 The Japanese Society of Toxicology
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