The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Collaborative work on evaluation of ovarian toxicity
4) Effects of fertility study of 4-vinylcyclohexene diepoxide in female rats
Terutaka KodamaJunichi YoshidaTadashi MiwaDaiki HasegawaTakeshi Masuyama
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2009 Volume 34 Issue Special Pages SP59-SP63


As part of a collaborative project, 4-vinylcyclohexene diepoxide (VCD), an ovarian toxicant, was intraperitoneally administered to female Sprague-Dawley rats at 0, 5, 20 or 80 mg/kg from 2 weeks prior to mating to Day 7 of gestation. At necropsy, the number of implanted embryos, rate of implantation decreased and the rate of preimplantation loss showed an increasing tendency in the 80 mg/kg group. As for organ weight, decreases in absolute and relative ovary weight were observed in the 80 mg/kg group. Histopathologically, the ovaries showed a decrease in number of small follicles at 80 mg/kg.

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© 2009 The Japanese Society of Toxicology
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