The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
PRELIMINARY DOSE FINDING STUDY FOR SUBACUTE TOXICOLOGICAL STUDY OF PRAVASTATIN SODIUM IN MONKEYS
Sunao MANABESeiji SUDOKazuo YAMASHITANobuhiro MIYAKOSHINaochica MATSUNUMAHiroshi MASUDA
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Keywords: monkey
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1989 Volume 14 Issue SupplementI Pages 41-55

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Abstract

Pravastatin sodium was orally administered to cynomolgus monkeys at dosage levels of 50, 200 and 800 mg/kg/day for 7 successive days. Excretions of diarrhea and/or loose stool were observed in the more than 50 mg/kg dose group, but the changes were quite mild. Animals of the 800 mg/kg dose group showed vomiting, diarrhed and/or excretion of soft stool and reduction of cholesterol content in serum. In conclusion, it is estimated that the no effective level is less than 200 mg/kg because no abnormalities were observed except for only very slight excretions of diarrhea and/or loose stool, and that the effective dose is 800 mg/kg in which vomiting was observed.

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