REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF 6-AMIDINO-2-NAPHTHYL 4-[(4, 5-DIHYDRO-1H-IMIDAZOL-2-YL) AMINO] BENZOATE DIMETHANESULFONATE (FUT-187) (IV) : Oral Administration to New Zealand White Rabbits During the Period of Fetal Organogenesis

Abstract

Oral administration of 6-amidino-2-naphthyl 4-[(4, 5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) at doses of 10, 30 and l00 mg/kg was given to New Zealand White rabbits on days 6 to 18 of gestation. The following results were obtained. Decreased food consumption and suppression of body weight gain in dams were observed and these changes contributed to the increase in aborted or prematured births and increased fetal mortality at the l00 mg/kg group. There were changed attributable to FUT-187 on external, skeletal and visceral examinations of fetuses. Based on the above, the no-effect dose level in dams and fetuses in the present study is 30 mg/kg/day.