The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
OCCURRENCE OF AUTOANTIBODY TO PROTEIN DISULFIDE ISOMERASE IN RATS WITH XENOBIOTIC-INDUCED HEPATITIS
Sekio NAGAYAMATsuyoshi YOKOIYasuro KAWAGUCHITetsuya KAMATAKI
Author information
JOURNALS FREE ACCESS

Volume 19 (1994) Issue 3 Pages 155-161

Details
Download PDF (835K) Contact us
Abstract

The occurrence of an autoantibody to protein disulfide isomerase (PDI) in rats after administration of various hepatotoxic drugs was investigated by immunoblotting and radioimmunoassay. An anti-PDI autoantibody was detected with high frequency in rats treated with D-galactosamine, acetaminophen with diethylmaleate, and carbon tetrachloride with diethylmaleate. The antibody-positive rate was relatively low in the groups of rats given carbon tetrachloride, acetaminophen or DL-ethionine alone. The anti-PDI antibody was not detected in rats treated with diethylmaleate alone. Although the mechanism of the production of the anti-PDI autoantibody is unclear, the occurrence of anti-PDI antibody correlated with high serum GPT activities. It is suggested that the autoantibody plays an important role in the development and persistence of drug-induced hepatitis.

Information related to the author
© The Japanese Society of Toxicology Headquarters
Previous article Next article

Altmetrics
Recently visited articles
feedback
Top