The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
MUTAGENICITY STUDIES WITH PALM FRUIT CAROTENE
Mitsuteru MASUDAMitsuru HARESAKUToshiharu TAKEITsuneaki NAKAMURA
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Keywords: Micronucleus test
JOURNALS FREE ACCESS

1995 Volume 20 Issue 5 Pages 619-627

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Abstract

The mutagenicity of palm fruit carotene was examined using the reverse mutation test with bacteria, the chromosomal aberration test with mammalian cells and the micronucleus test in mice. The carotene induced neither reverse mutation in Salmonella typhimurium TA98, TA1537, TA100, TA1535 and in Escherichia coli WP2uvrA, nor structural and numerical (polyploidy) chromosomal aberrations in the Chinese hamster fibroblast cell line (CHL). In addition, no increase in micronucleated polychromatic erythrocytes was elicited in the micronucleus test in CD-1(ICR) male mice. It is concluded that palm fruit carotene had no mutagenic activity in these in vitro and in vivo tests.

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