EFFECT OF FENITROTHION ON EXPERIMENTAL ALLERGIC CONJUNCTIVITIS

Abstract

The effect of fenitrothion on experimental allergic conjunctivitis was studied using guinea pigs. Guinea pigs were passively sensitized with anti-sera against ovalbumin (OVA) or Japanese cedar pollen. Eight days after the sensitization, 6×10^-5 mg/kg to 6 mg/kg of fenitrothion were administered subcutaneously. Two days after the injection, OVA or Japanese cedar pollen was given in the conjunctival sac and the allergic conjunctivitis was examined. OVA or Japanese cedar pollen induced the allergic conjunctivitid, depending on the challenge dosage (OVA). However, no adverse effect of fenitrothion was observed on allergic conjunctivitis challenged with OVA or Japanese cedar pollen. An anti-allergic agent, ketotifen, suppressed the allergic intensity. These results indicate that fenitrothion has no adverse effect on the experimental allergic conjunctivitis.