The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
EFFECT OF METHYL BROMIDE ON CULTURED MAMMALIAN CELLS
Masaru NISHIMURAMakoto UMEDASumiko ISHIZUMinoru SATO
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キーワード: direct action
ジャーナル フリー

1980 年 5 巻 4 号 p. 321-330

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抄録

Cytotioxicity of methyl bromide on cultured mammalian cells was examined. Lethal concentrations of methyl bromide on HeLa cells and primary cultured muscle, kidney and brain cells were similar (10 μg/ml). Acute toxic effect was induced by methyl bromide itself. And its cytotoxicity was reduced in the presence of glutathione. The action of methyl bromide seemed to be nonspecific protoplasm-toxic.

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