1981 Volume 6 Issue 3 Pages 191-202
Orally administered cadmium has been known to cause diarrhea and flatulence of the gastrointestinal tract. Scanning electron micro-scopic observations revealed that the absorptive cells on the tip of the intestinal villi were affected to some extent by administration of 2.5 μg CdSO4/10 g of body weight (b.w.). Administration of higher doses of CdSO4 made the microvilli of the absorptive cells sparse and caused degeneration of the cells. Strong enzymic activities of alkaline phosphatase, acid phosphatase, magnesium-dependent ATPase, and sodium-potassium-dependent ATPase were recognized at the microvilli of the absorptive cells of the villi in the control mice. The enzymic activities of magnesium-dependent ATPase and sodium-potassium -dependent ATPase became weak with increasing dosages of CdSO4. The microvilli of the absorptive cells showed a strong alkaline phosphatase activity at a dose less than 25 μg CdSO4/10 g of b. w., while some inhibitory effects could be recognized with 50 μg/10 g of b. w. After administration of 2.5 μg CdSO4/10 g of b. w., no acid phosphatase reaction products were found only at the absorptive cells located on the tip of the villi. Administration of a large quantity more than 5 μg/10 g of b. w. strongly affected the acid phosphatase activity. It may be possible that the digestive functions are impaired by low cadmium administration.