The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
CYTOTOXICITY OF CHLOROPEPTIDE IN ISOLATED HEPATOCYTES AND ITS INACTIVATION BY MICROSOMES
Yoshio UENO, Teruo ITO, Hiroko YOSHIZAWA-NAKAKI, Yoshiaki OMATA, Kohko ICHIMAN
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Keywords: cytochrome P-450
JOURNAL FREE ACCESS

1982 Volume 7 Issue 2 Pages 111-122

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Abstract

Chloropeptide, a hepatotoxic mycotoxin of Penicillium islandicum Sopp, induces gross changes in cell morphology including blebbing and ballooning of the cytoplasmic membrane in the isolated hepatocytes, and this hepatotoxic potential of chloropeptide is abolished by microsomal cytochrome P-450 system.

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