1989 Volume 11 Issue 4 Pages 361-370
Effects of intracerebroventricular (i. c. v.) administration of angiotensin Ⅱ (AⅡ) on renal sympathetic nerve activity (RSNA), arterial pressure, and heart rate were examined in rats anesthetized with a mixture of urethane and α-chloralose. Administration of AⅡ evoked an increase in arterial pressure and a decrease in RSNA with no significant change in heart rate. Prior i. c. v. administration of an AⅡ antagonist, saralasin, greatly attenuated the pressor response and inhibition of RSNA induced by i. c. v. AⅡ. Rats with sinoaortic denervation showed the same magnitude presser response and decrease in RSNA as intact animals. The result suggests that central AⅡ directly inhibits RSNA via AⅡ specific receptors.