Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Small Animal Medicine
Course of Antibody Titers After Administration of Antibacterial Agents in a Breeding Kennel with an Outbreak of Canine Brucellosis
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2013 Volume 66 Issue 2 Pages 115-120


Fourteen dogs reared in a breeding kennel where an outbreak of canine brucellosis was identified were shown to be positive for anti-Brucella canis antibodies by microtiter agglutination (MA) and ELISA. After being isolated from antibody-negative dogs, they were administered doxycycline hydrochloride and marbofloxacin. The positive rates of both tests declined until 8 weeks after the start of administration, after which they elevated again to 27.3% in the MA and 63.6% in the ELISA at week 16. These results demonstrate the usefulness of antibody tests for monitoring therapeutic efficacy and also suggest ELISA has high sensitivity in antibody detection. Meanwhile, 66 dogs at the same kennel found to be negative were treated with single-agent administrations of doxycycline hydrochloride, and both antibodies remained negative during the 32-week observation period. On the basis of these results, we concluded that tetracycline monotherapy can provide sufficient prevention of infection in antibody-negative dogs when other appropriate measures are immediately taken, such as isolation of infected dogs and disinfection of the facility.

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© 2013 Japan Veterinary Medical Association
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