Surveillance of D'Aguilar Virus in Kyoto Prefecture

Abstract

D'Aguilar virus (DAGV) that is an arthropod-borne virus suspected of being involved in bovine abnormal births, has been confirmed the domestic spread of infection mainly in the Kyushu-Okinawa region. Serological surveillance of DAGV was conducted using serum samples collected from 498 sentinel cattle in Kyoto Prefecture between 2005 and 2018. Neutralization antibodies against DAGV were detected in 17 cattle tested in 2013, 2017, and 2018. A DAGV-specific gene was amplified from the blood samples of 10 seropositive cattle tested in 2017 and 2018, and the virus was isolated from four of them that were collected in 2017. In Japan, this is the first detection of DAGV outside of the Kyushu-Okinawa region.