Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Experiments on Inhibitory Effects of Promazine Hydrochloride and Chlorpromazine Hydrochloride on Reactions of Arsenical
S. KOBAYASHII. OHISHIS. KOME
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JOURNAL FREE ACCESS

1959 Volume 12 Issue 10 Pages 432-436

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Abstract

It is well known that arsenicals are very effective adulticides among the chemotherapeutic agents for canine filariasis. However, they often cause emesis or nausea. Promazine hydrochloride and chlorpromazine hydrochloride are phenothiazine derivatives known as medicines causing artificial hibernation they are effective in preventing emesis and nausea. With this knowledge, the authors conducted the present experiments.
Three different preparations were injected:
(1) arsenical (0.75-1.00mg As/kg of dichlorophenarsin hdrochloride) only, (2) mixture of the arsenical (the same amount as above) and promazine hydrochloride (0.5-1.0mg/kg), and (3) mixture of the arsenical (the same amount as above) and chlorpromazine hydrochloride 1.0mg/kg. Compared with (1), the other two were markedly effective in preventing emesis and nausea. Dogs administered with these preparations retained normal appetite and vitality, proving the desirability of using promazine hydrochloride and chlorpromazine hydrochloride with arsenical. There was no significant difference in results of experiment between promazine hydrochloride and chlorpromazine hydrochloride when used with the arsenical.
Additional experiments were conducted with the lethal dose (4.0mg As/kg) of arsenical. Some dogs were administered with the arsenical and promazine hydrochloride (2.0and 5.0mg/kg), and others with the arsenical and chlorpromazine hydrochloride (5.0mg/kg). As a result, the former dogs died, while the latter survived. Reactions of shock produced by the lethal dose of arsenical were dramatically averted by chlorpromazine hydrochloride (5.0mg/kg) and the dogs maintained their appetite and vitality.

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