Electromyogram of Respiratory Muscle under Anesthesia by the Intravenous Route

Abstract

It is an ideal general, anesthesia when it is produced by a simple method of application without any side effect and maintains its effective, deep anesthetic stage as long as possible within a necessary extent. In order to produce anesthesia, it is rather infrequent at present to use only one of various anesthetics singly, but there is a tendency to administer some kinds of drugs simultaneously. In such cases, attention must be paid to the pharmacological characteristics, specificity of method of administration, and side effect in practical use of each anesthetic. Failure in anesthesia may not only deal a fatal blow to the subsequent clinical treatment, such as operation and therapy, but also lead animals to death frequently.
In clinical circles where there is always a problem how general anesthesia can be established precisely so as to facilitate succeeding treatment, it is absolutely necessary to determine any method of administration of anesthetic by the intravenous route with much safer and more effective results than any other method frequently employed at present. From this intention, the authors conducted a series of experiments.
As the interference with respiratory movement was pointed out as the most dangeous side effect of anesthetic introduced by the intravenous route, it was examined by electromyography. The resulting electromyograms were used for judgment.
From the results of experiments with single administration of rabonaru, a proprietary product of barbital derivative, it was made clear that the safest, most effective method consisted in injecting 25 mg/kg of this anesthetic by spending at least 2 minutes for the whole dose.