Therapeutic Effect of 2-Sulfamoyl-4, 4'-Diaminodiphenylsulfone (SDDS) on Acute Experimental Toxoplasmosis in Pigs

Abstract

Experiments were carried out to examine the chemotherapeutic effect of 2-Sulfamoyl-4, 4'-Diaminodiphenylsulfone (SDDS), which had been found very effective against experimental acute toxoplasmosis in pigs, as well as in mice.
Experiments were carried out to examine the chemotherapeutic effect of 2-Sulfamoyl-4, 4'-Diaminodiphenylsulfone (SDDS), which had been found very effective against experimental acute toxoplasmosis in pigs, as well as in mice.
The minimal effective dose that would kill the parasite completely when the medication was started on a day after the appearance of obvious symptoms of this disease could be estimated to be around 10 mg/kg which should be given once daily for 7 days. At lower doses, or when the medication was delayed until 4 days after the illness appeared, SDDS was also very effective for suppressing the symptoms, although the parasite still remained in one or a few tissues of the treated pigs.