Clinicopathological Findings on Bovine Amyloidosis

Abstract

Four dairy cows were affected with amyloidosis. They manifested persistent serous diarrhea, anorexia, edema, and emaciation. No treatment was successful and a poor prognosis made at 18-57 days of illness.
Biochemically, hypoproteinemia was serious, albumin and γ-globulin decreased, and α-globulin increased. Besides, α₂-macroglobulin and β-lipoprotein increased and IgG decreased remarkably. Proteinuria was intense.
Pathologically, amyloid nephrosis was severe. In almost all the organs amyloid deposition was noticed in small blood vessels and their perivascular connective tissue. Edematous changes were distinct in the digestive tract.
Amyloidosis may have been induced subsequently to chronic infections, which were chronic mastitis in all the cows and hepatic abscess in one cow.