1978 Volume 31 Issue 8 Pages 454-458
Forty-two dogs were administered with 5.5mg/kg of diethylcalbamazine (DEC) daily over a period from June to December every year for 13 years at most, or for 7.5 years on the average. Annual examination-revealed that all of them were negative for microfilariae in the blood and in good health. There was no significant difference in any component of serum reflecting the hepatic or renal function between the values determined in the period of administration and those in the other period of the year. In 7 dogs serum enzymatic activity was high, blood urea-nitrogenlevel 25 mg/dl, creatinine concentration 2.2 mg/dl, and hematocrit value 41.5%.