Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Effect of Levamisole on Blast Transformation of Lymphocytes in Bovine Chronic Mastitis
KATSUSHIGE NAKANO[in Japanese][in Japanese][in Japanese][in Japanese][in Japanese][in Japanese]
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1986 Volume 39 Issue 7 Pages 443-447


Ten cows with 25 quarters affected with chronic mastitis were orally given with a dose of 7.5 mg/kg of levamisole. Ten cows with 28 mastitic quarters were orally given with lactose as placebo dissolved in water. Nine healthy cows served as noninfected, nonmedicated controls. When examined 21 days later, the efficacy of the treatment was “excellent” or “good” in 72% of the 25 quarters of the levamisole-treated cows. Only one of the affected quarters was clinically recovered in the placebo-treated group.
The blast transformation of lymphocytes was examined 0, 3, 5, 7, 14 and 21 days after treatment. It was enhanced significantly 5 days after treatment. It was not enhanced in the placebo-treated or noninfected, nonmedicated cows.

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