Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Efficacy of Triclabendazole against Fasciola sp. in Naturally Infected Cattle
MASAO ABUKANJI SHIRAMIZU
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1987 Volume 40 Issue 7 Pages 481-484

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Abstract

A total of 52 cattle 3 to 10 years old naturally infected with liver flukes (Fasciola sp., ) were divided in to four groups. A control group consisted of 15 cattle. Groups A (8 cattle), B (13 cattle), and C (16 cattle) were administered orally with 3, 6, and 12mg/kg of triclabendazole, respectively. Group C maintained EPG at a zero level for 8 weeks. Biochemical analysis of the serum proved a decrease in γ-GTP and GLDH. These findings showed the fficacy of triclabendazole against liver flukes. Groups A and B also showed a decrease in EPG which failed, however, to reach a zore level. The dose of 3 to 6mg/kg was suggested to be insufficient. No side effects were recognized in any animal administered.

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