Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
The Effects of Adoptive Transfer of Immunity to Theileria sergenti Infection in Cattle
HIROYUKI KOYAMAYUKIKO NAGAIYUKIO YAGITOSHIMI OGASAWARATSUTOMU HOHDATSUHIROSHI SAITHO
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1988 Volume 41 Issue 9 Pages 640-644

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Abstract

Transfusion with neutrophils of cattle recovered from Theileria sergenti (TS) infection was performed to examine the effects on the percentage of parasitized erythrocytes (PPE) in peripheral blood of TS infected cattle. A cow recovered from an artificial infection with the Fukushima strain of TS showing the persistent low PPE was selected as a donor.
Leukocytes were obtained from 1 liter of a donor cow's blood and washed 3 times with a buffer solution by centrifugation. These leukocytes (more than 109 cells) were intravenously injected twice to the recipient cows at 3-day intervals. PPE in recipient cows rapidly decreased, but increased again to the previous value within a few days. The leukocyte transfusion was more effective when injected 5 times. However, the neutrophils from cattle not infected with TS showed no effects on PPE in the recipient cattle. Culture supernatant of co-culture with neutrophils from the donor cow recovered from TS infection and parasitized erythrocytes from the recipient cow was injected 8 times demonstrating no effects on PPE in the recipient cow. The PPE in the recipient cow was rapidly decreased after the blood transfusion from the donor cow as was the neutrophil transfusion.
These results suggested that the neutrophils of cows recovered from TS infection were effective to reduce the PPE in the cows highly infected with TS.

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