1989 Volume 42 Issue 2 Pages 116-119
Biochemical and immunological examinations were performed on a 2-year-old Holstein-Friesian heifer with skin leukosis. Acid phosphatase activity of the peripheral blood lymphocytes increased remarkably in stages when the cutaneous tumors were mulitple and predominant. Serum lactatedehydrogenase and isoenzyme activities were also elevated. These levels declined gradually with regression of the cutaneous tumors, and the tendency was intensified in the stage of complete regres-sion. Peripheral blood lymphocytes in the regression stage were well stimulated by T-cell mitogen. Suppression of lyphocytic blastogenetic activity by phytohemagglutinin or concanavalin A stimulation was evident in the tumorous stage, but not in the regressed stage of the affected heifer. Serum α1 acid glycoprotein was elevated in the predominant stgae and declined gradually as the cutaneous lesions were repressed.