Metastasized Case of Granulosa Cell Tumor in a Cow

Abstract

A granulosa cell tumor was found in a 2-year-old Holstein-Friesian cow, which was slaughtered to confirm an abdominal tumor and sterility. At autopsy, tumors varied in size were observed in the lungs and abdomen, and the ovary was not observed. Microscopically, neoplastic cells were observed in the lungs and some lymph nodes, and the tumor was diagnosed as the follicular type of granulosa cell tumor. The serum estrogen level was remarkably increased, especially the estrone (E1) level, but the estradiol (E2) level did not increased to any extent.