1995 Volume 48 Issue 11 Pages 875-878
Eighteen puppies naturally infected with Toxocara canis received orally 0.25 mg/kg milbemycin oxime (MO). In 12 dogs, eggs per gram feces (EPG) became negative by 30 days after treatment when no adult worms were recovered. In 4 dogs, the fecal EPG became negative by 7 days post-administration, while they harbored 1 to 3 mature or immature worms in the intestine at 30 days after administration. In the other 2 dogs, though fecal eggs disappeared by 7 days, a few eggs were detected in feces at 30th day. Of these 2 dogs given another 0.25 mg/kg, one excreted 1 worm at the 32nd day, while the other did not. At 30 days after re-treatment, fecal eggs were negative and no adult worms were recovered.