Journal of the Japan Veterinary Medical Association
Online ISSN : 2186-0211
Print ISSN : 0446-6454
ISSN-L : 0446-6454
Effect of Chinese Medicines (Kampo) on Antihistamine Reactivity and Mast-cell Degranulation in Dogs
Keiji OKADAHiroyasu KAZAKIKou TOGONobuyuki TOMIZAWAShigeo HARAYoshihiro KANEDA
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1995 Volume 48 Issue 9 Pages 673-676

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Abstract

Thirty-three healthy dogs were medicated with 1.50g/day of Sho-seiryu-to and 1.25g/day of Sho-fu-san, Touki-inshi or Sho-saiko-to, as chinese medicines, for a week, and the inhibitory effects on reactivity to histamine and mast-cell degranulation were evaluated by measuring skin wheal size at the injection site after intradermal injection with compound 48/80 or histamine phosphate. One week after medication, significant declines in these skin wheal sizes were observed with Touki-inshi (83.3%), Sho-saiko-to (77.4%) or Sho-seiryu-to (79.0%) in reaction to compound 48/80, and Sho-fu-san (75.6%), Sho-saiko-to (72.8%) or Sho-seryu-to (81.1%) in reaction to histamine phosphate. Blood cortisol concentrations were significantly higher after medication of Shosaiko-to and Sho-seiryu-to. These results are indicative of therapeutic effects of these 4 drugs to canine allergic dermatitis and pruritus.

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